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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically characterized by a focus on the practical aspects of the study design, such as recruitment and consent as well as adherence to the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid, and 프라그마틱 슬롯체험 it also reduces the chance of bias in the results. However, too much heterogeneity could cause issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used in lieu for explanation trials.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, 프라그마틱 슬롯 [bookmarkvids.com] dubbed PRECIS.2 This tool was designed to define the elements of a practical trial, including recruitment, design and delivery of the intervention, and the follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.